Pneumotox » Drug » Remifentanil

Remifentanil

The assault of Melnikov Street Theater in Moskow on October 26, 2002 was reportedly conducted using Remifentanil and Carfentanil that were pumped into the building (PMID 23002178)

Last update : 11/02/2015

IV.e Cough (acute, violent, explosive)

IX.d Respiratory failure from ventilatory depression (due to neuromuscular blockade/paralysis)

IX.p Disordered breathing during sleep - Sleep apnea

XI.g Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)

XI.r Death following exposure or poisoning

Diagnosing DIRD

Drug and radiation history

Drug singularity - Correct identification of the drug

Consistent timing of exposure v. onset of symptoms

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

Careful exlusion of another cause

Remission of symptoms with removal of drug

Recurrence with rechallenge (rarely advisable)

Causality assessment

More detailed checklist

The Drug-Induced Respiratory Disease Website