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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Remifentanil

1

IV.e Cough (acute, violent, explosive)

1
Last update : 13/09/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist

Publications

The impact of prophylactic intravenous lidocaine on opioid-induced cough: a meta-analysis of randomized controlled trials.
Journal of anesthesia 2014 Jun;28;325-33 2014 Jun
The incidence of cough induced by remifentanil during anesthetic induction was decreased by graded escalation of the remifentanil concentration.
Korean journal of anesthesiology 2010 Feb;58;117-21 2010 Feb
The effect of lidocaine on remifentanil-induced cough.
Anaesthesia 2008 May;63;495-8 2008 May

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