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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Kayexalate
2
Sodium poystyrene sulfonate
Last update :
17/06/2012
II - Pulmonary edema - Acute lung injury - ARDS
II.b
ARDS - Acute lung injury
1
IV - Airway involvement
IV.i
Foreign body aspiration bronchiolitis
2
XI - Miscellaneous
XI.g
Aspiration, aspiration pneumonia (w/wo demonstrable pharyngeal dysmotility)
2
XV - Pathology
XV.aq
Path: Resin (Kayexalate-Sevelamer) lung
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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