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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Teniposide

1

X.g Hypersensitivity reaction (may manifest with fever and/or skin, throat or airway involvement)

1
Last update : 17/05/2012
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Publications

Pulmonary complications of novel antineoplastic agents for solid tumors.
Chest 2008 Feb;133;528-38 2008 Feb
Hypersensitivity reactions to epipodophyllotoxins in children with acute lymphoblastic leukemia.
Cancer 1991 Feb 15;67;1070-5 1991 Feb 15
Teniposide-induced hypersensitivity reactions in children.
Lancet (London, England) 1989 Jul 01;2;55 1989 Jul 01
Anaphylactic reactions to teniposide.
Lancet (London, England) 1989 Feb 18;1;394 1989 Feb 18
Hypersensitivity reactions to teniposide (VM-26): an analysis.
Journal of clinical oncology : official journal of the American Society of Clinical Oncology 1986 Aug;4;1262-9 1986 Aug
Allergic reactions to teniposide in patients with neuroblastoma and lymphoid malignancies.
Cancer treatment reports 1985 Apr;69;439-41 1985 Apr

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