v2.2
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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Benfluorex
4
The drug was recalled in 2009-2010
Last update :
22/10/2012
V - Pleural and/or pericardial involvement
V.a
Pleural effusion (uni- or bilateral) (can accompany DI-LDs)
1
V.c
Pleural thickening
1
VI - Pulmonary vasculopathies
VI.b
Pulmonary arterial hypertension
2
XII - Cardiovascular involvement / toxicity
XII.b
Valvular heart disease and/or dysfunction
5
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dexfenfluramine
Fenfluramine
Weight loss-, slimming agents
