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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Benfluorex

4

XII.b Valvular heart disease and/or dysfunction

5
Last update : 26/01/2013
 
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Dexfenfluramine
3
Fenfluramine
3
Weight loss-, slimming agents
5

Publications

Fatal postoperative systemic pulmonary hypertension in benfluorex-induced valvular heart disease surgery: A case report.
Medicine 2017 Jan;96;e4985 2017 Jan
Adverse effects of benfluorex on heart valves and pulmonary circulation.
Pharmacoepidemiology and drug safety 2014 Jul;23;679-86 2014 Jul
Drug-induced valvular heart disease: an update.
Archives of cardiovascular diseases 2013 May;106;333-9 2013 May
Estimate of deaths due to valvular insufficiency attributable to the use of benfluorex in France.
Pharmacoepidemiology and drug safety 2012 Apr;21;343-51 2012 Apr
Echocardiographic evidence for valvular toxicity of benfluorex: a double-blind randomised trial in patients with type 2 diabetes mellitus.
PloS one 2012;7;e38273 2012
How can benfluorex-related heart valve disease be identified by echocardiography?
Archives of cardiovascular diseases 2011 Oct;104;489-92 2011 Oct
Valvular heart disease associated with benfluorex therapy: results from the French multicentre registry.
European journal of echocardiography : the journal of the Working Group on Echocardiography of the European Society of Cardiology 2011 Apr;12;265-71 2011 Apr

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