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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Bupropion, bupropion poisoning
2
Last update :
16/03/2024
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a
Angioedema (may cause UAO, asphyxia and death)
1
X - Systemic/Distant conditions, syndromes and reactions
X.a
DRES syndrome - DRESS-like reaction
1
X.p
Serum sickness-like reaction
1
XII - Cardiovascular involvement / toxicity
XII.g
Coronary artery disease (acute) - Myocardial ischemia/infarction
1
XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
1
XII.ah
Tachycardia
2
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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