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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Estrogens
3
Last update :
30/05/2013
I - Interstitial/parenchymal lung disease
I.as
Progression of preexisting pulmonary LAMM
1
VI - Pulmonary vasculopathies
VI.a
Pulmonary embolism - Venous thrombosis/thromboembolism
3
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a
Angioedema (may cause UAO, asphyxia and death)
1
XV - Pathology
XV.au
Path: Progression of pulmonary LAMM
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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Hormone replacement therapy
