Pneumotox » Drug » Montelukast

Montelukast

2

See also under LTRA and other LTRAs

Last update : 17/04/2015

I.c Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

1

III.a Alveolar hemorrhage (AH), diffuse AH (DAH)

1

VIII.a Angioedema (may cause UAO, asphyxia and death)

1

X.f Anaphylaxis-Anaphylactoid reaction (can be fatal)

-

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

2

X.ah Granulomatosis with polyangiitis (typically ANCA pos.) - GPA flare

1

Diagnosing DIRD

1

Drug and radiation history

2

Drug singularity - Correct identification of the drug

3

Consistent timing of exposure v. onset of symptoms

4

Clinical, imaging, BAL, pathological pattern consistent with the specific drug

5

Careful exlusion of another cause

6

Remission of symptoms with removal of drug

7

Recurrence with rechallenge (rarely advisable)

8

Causality assessment

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