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The Drug-Induced Respiratory Disease Website

Philippe Camus, M.D.

Dijon, France

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Montelukast

2

X.h Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

2
Last update : 04/09/2012
 
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Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
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Causality assessment
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See also under
Leukotriene receptor antagonists (LTRA)
3
Pranlukast
2
Zafirlukast
2

Publications

Montelukast-induced adverse drug reactions: a review of case reports in the literature.
Pharmacology 2014;94;60-70 2014
A case of Churg-Strauss syndrome treated with montelukast.
Medical principles and practice : international journal of the Kuwait University, Health Science Centre 2012;21;186-9 2012
Churg Strauss syndrome associated with montelukast--case report.
Pneumologia (Bucharest, Romania) 2012;61;113-6 2012
Churg-Strauss syndrome related to montelukast.
Tuberkuloz ve toraks 2012;60;56-8 2012
Association between leukotriene receptor antagonist therapy and Churg-Strauss syndrome: an analysis of the FDA AERS database.
Thorax 2010 Feb;65;132-8 2010 Feb
Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist.
Clinical and experimental nephrology 2010 Dec;14;602-7 2010 Dec
Churg-Strauss syndrome associated with montelukast therapy.
The Journal of asthma : official journal of the Association for the Care of Asthma 2009 Aug;46;604-5 2009 Aug
Montelukast and Churg-Strauss syndrome.
Swiss medical weekly 2004 Jun 26;134;377-80 2004 Jun 26
Churg-Strauss syndrome in two patients receiving montelukast.
Rheumatology (Oxford, England) 2002 May;41;535-9 2002 May
Churg-Strauss syndrome associated with montelukast.
Postgraduate medical journal 2001 Jun;77;390-1 2001 Jun

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