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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
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Itraconazole
1
Last update :
20/01/2012
III - Pulmonary/alveolar./airway hemorrhage/bleeding
III.a
Alveolar hemorrhage (AH), diffuse AH (DAH)
-
V - Pleural and/or pericardial involvement
V.m
Pleuropericarditis - Pleuropericardial effusion (ANA unknown or negative)
1
VIII - Central-large-upper airway (incl. pharyngeal-nasal) involvement
VIII.a
Angioedema (may cause UAO, asphyxia and death)
1
X - Systemic/Distant conditions, syndromes and reactions
X.f
Anaphylaxis-Anaphylactoid reaction (can be fatal)
1
XII - Cardiovascular involvement / toxicity
XII.r
Heart failure (biventricular, congestive)
1
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
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