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Diagnosing DIRD
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The Drug-Induced Respiratory Disease Website
Philippe Camus, M.D.
Dijon, France
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Drugs
Patterns
Theophylline
3
Toxicity appears to be dose- and plasma level-related
Last update :
03/05/2019
X - Systemic/Distant conditions, syndromes and reactions
X.ba
Rhabdomyolysis (see also under Xj)
1
XI - Miscellaneous
XI.d
Metabolic acidosis (incl. lactic acidosis/-gap). May cause hyperpnea/dyspnea
1
XI.r
Death following exposure or poisoning
2
XII - Cardiovascular involvement / toxicity
XII.l
Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)
3
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Identify causative drugs
Diagnosing DIRD
1
Drug and radiation history
2
Drug singularity - Correct identification of the drug
3
Consistent timing of exposure v. onset of symptoms
4
Clinical, imaging, BAL, pathological pattern consistent with the specific drug
5
Careful exlusion of another cause
6
Remission of symptoms with removal of drug
7
Recurrence with rechallenge (rarely advisable)
8
Causality assessment
More detailed checklist
See also under
Bezoars, pharmacobezoars, body packing
