Philippe Camus, M.D.

Dijon, France

Both apps are now back!

Back

The Drug-Induced Respiratory Disease Website and App

Alendronate - Alendronic acid

Alendronate may cause severe laryngotracheal injury following pill aspiration into the aiway, representing pill- rather or as opposed to true drug-induced respiratory disease.

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV - Airway involvement

IV.m

Lolalized airway inflammation/burgeoning/stenosis: The pill aspiration syndrome

V - Central-large-upper airway (incl. pharyngeal-nasal) involvement

V.i

Thermal (burns, frostbite), chemical or caustic injury on the face, mouth, tongue, pharynx or upper airway
V.ae

Osteonecrosis of the jaw

X - Systemic/Distant conditions, syndromes and reactions

X.b

Antiphospholipid antibodies w/wo the APL syndrome

XIII - Esophageal involvement

XIII.a

Dysphagia
XIII.d

Esophageal toxicity

XIX - Pathology

XIX.av

Path: Foreign body reaction in large airway walls