The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.o

Pulmonary alveolar proteinosis (PAP)

Publications

Kedia RK, Sullivan A, Stephens M, Allen MB

A breathless female.

The European respiratory journal 1999 Jan;13;207-9 — 1999 Jan — 207-9

Aymard JP, Gyger M, Lavallee R, Legresley LP, Desy M

A case of pulmonary alveolar proteinosis complicating chronic myelogenous leukemia. A peculiar pathologic aspect of busulfan lung?

Cancer 1984 Feb 15;53;954-6 — 1984 Feb 15 — 954-6