The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.a

DRES syndrome - DRESS-like reaction

Publications

AlTarrah D, ElSamra Z, Daher W, AlKhas A, Alzafiri L

A cross-sectional study of self-reported dietary supplement use, associated factors, and adverse events among young adults in Kuwait.

Journal of health, population, and nutrition. 2024;43(1):117

Doan KD, Akinsanya A, Kuhar M, Mesa H

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology. 2023;19(1):92

Ghandourah H, Bhandal S, Brundler MA, Noseworthy M

Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.

BMJ case reports. 2016;2016

Deshmukh P, Dao H, Parrisbalogun S, Locala JA

Lamotrigine-induced anticonvulsant hypersensitivity syndrome associated with acute respiratory distress syndrome.

Psychosomatics. 2011;52(5):495-7

Amante MF, Filippini AV, Cejas N, Lendoire J, Imventarza O, Parisi C

Dress syndrome and fulminant hepatic failure induced by lamotrigine.

Annals of hepatology. 2009;8(1):75-7

Chang CC, Shiah IS, Yeh CB, Wang TS, Chang HA

Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.

Progress in neuro-psychopharmacology & biological psychiatry. 2006;30(4):741-4

Knowles SR, Uetrecht J, Shear NH

Idiosyncratic drug reactions: the reactive metabolite syndromes.

Lancet (London, England). 2000;356(9241):1587-91

Schaub N, Bircher AJ

Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.

Allergy. 2000;55(2):191-3