The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIX.a

DRES syndrome - DRESS-like reaction

Publications

AlTarrah D, ElSamra Z, Daher W, AlKhas A, Alzafiri L

A cross-sectional study of self-reported dietary supplement use, associated factors, and adverse events among young adults in Kuwait.

Journal of health, population, and nutrition 2024 Aug 08;43;117 — 2024 Aug 08 — 117

Doan KD, Akinsanya A, Kuhar M, Mesa H

Fatal eosinophilic myocarditis and submassive hepatic necrosis in lamotrigine induced DRESS syndrome.

Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology 2023 Oct 25;19;92 — 2023 Oct 25 — 92

Ghandourah H, Bhandal S, Brundler MA, Noseworthy M

Bronchiolitis obliterans organising pneumonia associated with anticonvulsant hypersensitivity syndrome induced by lamotrigine.

BMJ case reports 2016 Jan 29;2016; — 2016 Jan 29

Deshmukh P, Dao H, Parrisbalogun S, Locala JA

Lamotrigine-induced anticonvulsant hypersensitivity syndrome associated with acute respiratory distress syndrome.

Psychosomatics 2011 Sep-Oct;52;495-7 — 2011 Sep-Oct — 495-7

Amante MF, Filippini AV, Cejas N, Lendoire J, Imventarza O, Parisi C

Dress syndrome and fulminant hepatic failure induced by lamotrigine.

Annals of hepatology 2009;8;75-7 — 2009 — 75-7

Chang CC, Shiah IS, Yeh CB, Wang TS, Chang HA

Lamotrigine-associated anticonvulsant hypersensitivity syndrome in bipolar disorder.

Progress in neuro-psychopharmacology & biological psychiatry 2006 Jun;30;741-4 — 2006 Jun — 741-4

Knowles SR, Uetrecht J, Shear NH

Idiosyncratic drug reactions: the reactive metabolite syndromes.

Lancet (London, England) 2000 Nov 04;356;1587-91 — 2000 Nov 04 — 1587-91

Schaub N, Bircher AJ

Severe hypersensitivity syndrome to lamotrigine confirmed by lymphocyte stimulation in vitro.

Allergy 2000 Feb;55;191-3 — 2000 Feb — 191-3