The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Mainly described in the context of calcium channel blocker poisoning/overdose

Publications

Izdes S, Altintas ND, Soykut C

Acute respiratory distress syndrome after verapamil intoxication: case report and literature review.

Acta clinica Belgica. 2014;69(2):116-9

Siddiqi TA, Hill J, Huckleberry Y, Parthasarathy S

Non-cardiogenic pulmonary edema and life-threatening shock due to calcium channel blocker overdose: a case report and clinical review.

Respiratory care. 2014;59(2):e15-21

Sawatzki M, Kummer O, Krähenbühl S, Siegemund M

[Seizure and non-cardiogenic pulmonary edema after intoxication].

Der Internist. 2010;51(4):528-32

Sami Karti S, Ulusoy H, Yandi M, Gündüz A, Koşucu M, Erol K, Ratip S

Non-cardiogenic pulmonary oedema in the course of verapamil intoxication.

Emergency medicine journal : EMJ. 2002;19(5):458-9

Brass BJ, Winchester-Penny S, Lipper BL

Massive verapamil overdose complicated by noncardiogenic pulmonary edema.

The American journal of emergency medicine. 1996;14(5):459-61

Leesar MA, Martyn R, Talley JD, Frumin H

Noncardiogenic pulmonary edema complicating massive verapamil overdose.

Chest. 1994;105(2):606-7

Witchitz S, Haiat R, Tarrade T, Chiche P

[Cardiovascular complications during treatment by verapamil. A propos of 6 cases].

La Nouvelle presse medicale. 1975;4(5):337-8