The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IV.f

Severe or catastrophic bronchospasm or asthma attack (can be fatal)

Can be fatal in minutes

Publications

Morales DR, Lipworth BJ, Donnan PT, Jackson C, Guthrie B

Respiratory effect of beta-blockers in people with asthma and cardiovascular disease: population-based nested case control study.

BMC medicine. 2017;15(1):18

Johnston SL, Edwards MR

Mechanisms of adverse effects of {beta}-agonists in asthma.

Thorax. 2009;64(9):739-41

Spitz DJ

An unusual death in an asthmatic patient.

The American journal of forensic medicine and pathology. 2003;24(3):271-2

Fallowfield JM, Marlow HF

Propranolol is contraindicated in asthma.

BMJ (Clinical research ed.). 1996;313(7070):1486

Leuppi JD, Hartmann K, Ciociaro C, Reinhart WH, Kuhn M

[Side effects of drugs on the respiratory tract: experiences of the Swiss Drug Monitoring Center from 1991 to 1995].

Praxis. 1996;85(44):1394-7