The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VI.b

Pulmonary arterial hypertension

Publications

Hendricks EJ, Rothman RB

RE: Pulmonary hypertension associated with use of phentermine?

Yonsei medical journal. 2011;52(5):869-70

Bang WD, Kim JY, Yu HT, Cho SS, Jang JY, Oh CM, Joung B, Chang HJ

Pulmonary hypertension associated with use of phentermine.

Yonsei medical journal. 2010;51(6):971-3

Tomita T, Zhao Q

Autopsy findings of heart and lungs in a patient with primary pulmonary hypertension associated with use of fenfluramine and phentermine.

Chest. 2002;121(2):649-52

Fishman AP

Aminorex to fen/phen: an epidemic foretold.

Circulation. 1999;99(1):156-61

Mark EJ, Patalas ED, Chang HT, Evans RJ, Kessler SC

Fatal pulmonary hypertension associated with short-term use of fenfluramine and phentermine.

The New England journal of medicine. 1997;337(9):602-6