The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Matsumoto M, Ohga M, Uemura S

Late onset interstitial pneumonia induced by bepridil: A case report.

Journal of arrhythmia. 2015;31(1):47-9

Yamasaki K, Yatera K, Noguchi S, Oda K, Akata K, Nishida C, Kawanami T, Kawanami Y, Ishimoto H, Ono S, Wakuta Y, Mukae H

Incidence and outcomes of bepridil-induced interstitial pneumonia.

Respiratory medicine. 2013;107(12):2088-91

Suzuki T, Hanaoka M, Yokoyama T, Koizumi T, Kubo K

Gradual progression of interstitial pneumonia induced by bepridil.

Internal medicine (Tokyo, Japan). 2009;48(23):2033-5

Watanabe M, Takata Y, Fukasawa S, Sakota K, Abe T, Goseki Y, Setoguchi Y, Chikamori T, Yamashina A

Two patients with bepridil-induced interstitial pneumonia.

Circulation journal : official journal of the Japanese Circulation Society. 2009;73(7):1352-5

Okubo F, Ando M, Ashihara Y, Okubo T, Nishitake T, Ito T, Matsuno O, Fukami T, Miyazaki E, Kumamoto T

[A case of drug-induced pneumonitis due to bepridil].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society. 2006;44(1):17-21

Gaku S, Naoshi K, Teruhiko A

A case of bepridil induced interstitial pneumonitis.

Heart (British Cardiac Society). 2003;89(12):1415