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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.a

Left or biventricular dysfunction/failure

Publications

Immordino L, Connolly S, Crijns H, Roy D, Capucci A, Radzik D, Aliot E, Hohnloser S, Kowey P

Effects of dronedarone started rapidly after amiodarone discontinuation.

Clinical cardiology. 2013;36(2):88-95

De Ferrari GM, Dusi V

Drug safety evaluation of dronedarone in atrial fibrillation.

Expert opinion on drug safety. 2012;11(6):1023-45

Coons JC, Plauger KM, Seybert AL, Sokos GG

Worsening heart failure in the setting of dronedarone initiation.

The Annals of pharmacotherapy. 2010;44(9):1496-500

Køber L, Torp-Pedersen C, McMurray JJ, Gøtzsche O, Lévy S, Crijns H, Amlie J, Carlsen J, Dronedarone Study Group

Increased mortality after dronedarone therapy for severe heart failure.

The New England journal of medicine. 2008;358(25):2678-87