The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.h

Eosinophilic granulomatosis with polyangiitis (Churg-Strauss)

Publications

Calapai G, Casciaro M, Miroddi M, Calapai F, Navarra M, Gangemi S

Montelukast-induced adverse drug reactions: a review of case reports in the literature.

Pharmacology. 2014;94(1-2):60-70

Man MA, Alexandrescu D, Pop M, Trofor A

Churg Strauss syndrome associated with montelukast--case report.

Pneumologia (Bucharest, Romania). 2012;61(2):113-6

Uyar M, Elbek O, Bakır K, Kibar Y, Bayram N, Dikensoy Ö

Churg-Strauss syndrome related to montelukast.

Tuberkuloz ve toraks. 2012;60(1):56-8

Anar C, Ünsal I, Ozanturk ME, Halilçolar H, Yucel N

A case of Churg-Strauss syndrome treated with montelukast.

Medical principles and practice : international journal of the Kuwait University, Health Science Centre. 2012;21(2):186-9

Kanda T, Tanio H, Wu C, Nishihara H, Nogaki F, Ono T

Churg-Strauss syndrome with severe granulomatous angiitis and crescentic glomerulonephritis, which developed during therapy with a leukotriene receptor antagonist.

Clinical and experimental nephrology. 2010;14(6):602-7

Bibby S, Healy B, Steele R, Kumareswaran K, Nelson H, Beasley R

Association between leukotriene receptor antagonist therapy and Churg-Strauss syndrome: an analysis of the FDA AERS database.

Thorax. 2010;65(2):132-8

Kaliterna DM, Perković D, Radić M

Churg-Strauss syndrome associated with montelukast therapy.

The Journal of asthma : official journal of the Association for the Care of Asthma. 2009;46(6):604-5

Conen D, Leuppi J, Bubendorf L, Ronsdorf A, Tamm M, Hauser T

Montelukast and Churg-Strauss syndrome.

Swiss medical weekly. 2004;134(25-26):377-80

Guilpain P, Viallard JF, Lagarde P, Cohen P, Kambouchner M, Pellegrin JL, Guillevin L

Churg-Strauss syndrome in two patients receiving montelukast.

Rheumatology (Oxford, England). 2002;41(5):535-9

Mukhopadhyay A, Stanley NN

Churg-Strauss syndrome associated with montelukast.

Postgraduate medical journal. 2001;77(908):390-1