The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Virzì F, Giacopelli G, Tutone P, Profera L, Giarratano A, Raineri SM, Tomasello S, Accurso G

Acute eosinophilic pneumonia associated with mefloquine prophylaxis: A case report.

Respiratory medicine case reports 2025;56;102238 — 2025 — 102238

Katsenos S, Psathakis K, Nikolopoulou MI, Constantopoulos SH

Mefloquine-induced eosinophilic pneumonia.

Pharmacotherapy 2007 Dec;27;1767-71 — 2007 Dec — 1767-71

Soentjens P, Delanote M, Van Gompel A

Mefloquine-induced pneumonitis.

Journal of travel medicine 2006 May-Jun;13;172-4 — 2006 May-Jun — 172-4

Inoue T, Tanaka E, Sakuramoto M, Minakuchi M, Maeda Y, Maniwa K, Terada K, Goto S, Takeda T, Noma S, Taguchi Y

[Case of drug-induced pneumonia possibly due to mefloquine (antimalarial drug)].

Nihon Kokyuki Gakkai zasshi = the journal of the Japanese Respiratory Society 2005 Feb;43;103-7 — 2005 Feb — 103-7

Davidson AC, Bateman C, Shovlin C, Marrinan M, Burton GH, Cameron IR

Pulmonary toxicity of malaria prophylaxis.

BMJ (Clinical research ed.) 1988 Nov 12;297;1240-1 — 1988 Nov 12 — 1240-1