The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.e

ARDS - Acute lung injury

Publications

Kluger N, Bessis D, Guillot B, Girard C

Acute respiratory distress syndrome complicating generalized pustular psoriasis (psoriasis-associated aseptic pneumonitis).

Journal of the American Academy of Dermatology 2011 Jun;64;1154-8 — 2011 Jun — 1154-8

Martzolff L, Huber M, Dukic R, Thannberger P, Kieffer C, Kieffer P

[Acitretin-induced pneumonia: an underestimated complication of treatment of psoriasis].

La Revue de medecine interne 2008 May;29;393-6 — 2008 May — 393-6

Cuhadaroglu C, Korular D, Erelel M, Kiyan E, Kiliçaslan Z

Respiratory distress with acitretin, reversal by corticosteroid.

Dermatology online journal 2001 Dec;7;5 — 2001 Dec — 5