The Drug-Induced Respiratory Disease Website and App

BCG therapy (topical instillations in the urinary bladder)

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (interstitial lung disease/ILD)

Publications

Yoshioka F, Kato T, Shima Y, Hatano K, Kawashima A, Fukuhara S, Imamura R, Nonomura N

Drug-induced interstitial pneumonia after intravesical Bacillus Calmette-Guerin administration for bladder cancer with scleroderma.

IJU case reports 2023 Mar;6;133-136 — 2023 Mar — 133-136

Spisarova M, Losse S, Jakubec P, Hartmann I, Kral M, Ehrmann J, Szkorupa M, Studentova H, Melichar B

Bacillus Calmette-Guérin pneumonitis after intravesical instillation: Report of two cases and a review of the literature.

Biomedical papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia 2023 Jan 02;; — 2023 Jan 02

Pommier JD, Ben Lasfar N, Van Grunderbeeck N, Burdet C, Laouénan C, Rioux C, Pierre-Audigier C, Meybeck A, Choudat L, Benchikh A, Nguyen S, Bouvet E, Yeni P, Yazdanpanah Y, Joly V

Complications following intravesical bacillus Calmette-Guerin treatment for bladder cancer: a case series of 22 patients.

Infectious diseases (London, England) 2015;47;725-31 — 2015 — 725-31

Tobiume M, Shinohara T, Kuno T, Mukai S, Naruse K, Hatakeyama N, Ogushi F

BCG-induced pneumonitis with lymphocytic pleurisy in the absence of elevated KL-6.

BMC pulmonary medicine 2014 Mar 05;14;35 — 2014 Mar 05 — 35

Caramori G, Artioli D, Ferrara G, Cazzuffi R, Pasquini C, Libanore M, Guardigni V, Guzzinati I, Contoli M, Rossi R, Rinaldi R, Contini C, Papi A

Severe pneumonia after intravesical BCG instillation in a patient with invasive bladder cancer: case report and literature review.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2013 Mar;79;44-8 — 2013 Mar — 44-8

Um SJ, Lee SK, Yang DK

Hypersensitivity pneumonitis following intravesical bacille Calmette-Guérin immunotherapy for superficial bladder cancer.

Journal of investigational allergology & clinical immunology 2009;19;230-2 — 2009 — 230-2

Salajka F, Pokorny A, Vomela J, Pacík D, Krpensky A, Hrazdirovà A

Severe complications following intravesical BCG instillation.

Monaldi archives for chest disease = Archivio Monaldi per le malattie del torace 2002 Oct-Dec;57;321-4 — 2002 Oct-Dec — 321-4

Iantorno R, Nicolai M, Storto ML, Ciccotosto C, Cipollone G, Mastroprimiano G, Tenaglia RL

Miliary tuberculosis of the lung in a patient treated with bacillus Calmette-Guerin for superficial bladder cancer.

The Journal of urology 1998 May;159;1639-40 — 1998 May — 1639-40

Israel-Biet D, Venet A, Sandron D, Ziza JM, Chretien J

Pulmonary complications of intravesical Bacille Calmette-Guérin immunotherapy.

The American review of respiratory disease 1987 Mar;135;763-5 — 1987 Mar — 763-5

Orihuela E, Herr HW, Pinsky CM, Whitmore WF

Toxicity of intravesical BCG and its management in patients with superficial bladder tumors.

Cancer 1987 Aug 01;60;326-33 — 1987 Aug 01 — 326-33

McParland C, Cotton DJ, Gowda KS, Hoeppner VH, Martin WT, Weckworth PF

Miliary Mycobacterium bovis induced by intravesical bacille Calmette-Guérin immunotherapy.

The American review of respiratory disease 1992 Nov;146;1330-3 — 1992 Nov — 1330-3