The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

III.b

Pneumorenal syndrome (w/wo ANCAs)

Publications

Russe-Russe JR, Pellegrini JR Jr, Alvarez-Betancourt A, Munshi RF, Anand P

Fulminant Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis After 10 Years of Hydralazine Use.

Cureus. 2021;13(10):e18974

Doughem K, Battisha A, Sheikh O, Konduru L, Madoukh B, Al-Sadawi M, Shaikh S

Hydralazine-Induced ANCA Associated Vasculitis (AAV) Presenting with Pulmonary-Renal Syndrome (PRS): A Case Report with Literature Review.

Current cardiology reviews. 2021;17(2):182-187

Al-Abdouh A, Siyal AM, Seid H, Bekele A, Garcia P

Hydralazine-induced antineutrophil cytoplasmic antibody-associated vasculitis with pulmonary-renal syndrome: a case report.

Journal of medical case reports. 2020;14(1):47

Tsai-Nguyen G, Modrykamien AM, Bredeweg A

Hereditary afibrinogenemia and pulmonary-renal hydralazine-induced vasculitis.

Proceedings (Baylor University. Medical Center). 2019;32(3):397-398

Marina VP, Malhotra D, Kaw D

Hydralazine-induced ANCA vasculitis with pulmonary renal syndrome: a rare clinical presentation.

International urology and nephrology. 2012;44(6):1907-9

Kalra A, Yokogawa N, Raja H, Palaniswamy C, Desai P, Zanotti-Cavazzoni SL, Rajaram SS

Hydralazine-induced pulmonary-renal syndrome: a case report.

American journal of therapeutics. 2012;19(4):e136-8

Yokogawa N, Vivino FB

Hydralazine-induced autoimmune disease: comparison to idiopathic lupus and ANCA-positive vasculitis.

Modern rheumatology. 2009;19(3):338-47