The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

IX.a

Diaphragm/inspiratory muscle weakness/paralysis (w/wo ARF)

Publications

Fernández-Delgado E, Egea-Guerrero JJ, Freire-Aragón MD, Rivera-Fernández V, Durán-Martínez P

[Severe respiratory failure and neuromuscular blockade after administration of colimycin].

Medicina intensiva. 2015;39(7):448-9

Fernández AB, Pérez M, Soto L

Sudden respiratory muscle paralysis and apnea in a patient infected with multidrug-resistant Pseudomonas aeruginosa treated with intravenous colistin.

International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases. 2013;17(5):e357

Wahby K, Chopra T, Chandrasekar P

Intravenous and inhalational colistin-induced respiratory failure.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America. 2010;50(6):e38-40

Aldrich TK, Prezant DJ

Adverse effects of drugs on the respiratory muscles.

Clinics in chest medicine. 1990;11(1):177-89