The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.r

Pulmonary nodulosis

Publications

Akiyama N, Toyoshima M, Kono M, Nakamura Y, Funai K, Suda T

Methotrexate-induced Accelerated Pulmonary Nodulosis.

American journal of respiratory and critical care medicine 2015 Jul 15;192;252-3 — 2015 Jul 15 — 252-3

Manuel A, Jones Q, Wiggins J

Multiple pulmonary nodules in a male with psoriatic arthritis.

European respiratory review : an official journal of the European Respiratory Society 2010 Jun;19;164-5 — 2010 Jun — 164-5

Balbir-Gurman A, Guralnik L, Best LA, Vlodavsky E, Yigla M, Menahem Nahir A, Braun-Moscovici Y

Accelerated pulmonary nodulosis and sterile pleural effusion in a patient with psoriatic arthropathy during methotrexate therapy: a case report.

Journal of clinical rheumatology : practical reports on rheumatic & musculoskeletal diseases 2009 Feb;15;29-30 — 2009 Feb — 29-30

Steeghs N, Huizinga TW, Dik H

Bilateral hydropneumothoraces in a patient with pulmonary rheumatoid nodules during treatment with methotrexate.

Annals of the rheumatic diseases 2005 Nov;64;1661-2 — 2005 Nov — 1661-2

Agarwal V, Aggarwal A, Misra R

Methotrexate induced accelerated nodulosis.

The Journal of the Association of Physicians of India 2004 Jul;52;538-40 — 2004 Jul — 538-40

Filosa G, Salaffi F, Bugatti L

Accelerated nodulosis during methotrexate therapy for refractory rheumatoid arthritis. A case report.

Advances in experimental medicine and biology 1999;455;521-4 — 1999 — 521-4

Kerstens PJ, Boerbooms AM, Jeurissen ME, Fast JH, Assmann KJ, van de Putte LB

Accelerated nodulosis during low dose methotrexate therapy for rheumatoid arthritis. An analysis of ten cases.

The Journal of rheumatology 1992 Jun;19;867-71 — 1992 Jun — 867-71