The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.at

Amiodarone pulmonary toxicity - Amiodarone lung

Publications

Teraguchi M, Komatsu T, Akamada Y, Nabeta T, Fukaya H, Ako J, Otori K

Optimizing Amiodarone Maintenance Dose to Minimize N-Desethylamiodarone Accumulation and Pulmonary Toxicity: Insights from Machine Learning and Pharmacokinetic Simulation.

Clinical drug investigation. 2026;46(9):1037-1045

Camus P, Mehendale HM

Pulmonary sequestration of amiodarone and desethylamiodarone.

The Journal of pharmacology and experimental therapeutics. 1986;237(3):867-73