The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

VII.b

Pulmonary arterial hypertension

Publications

Poisson C, Hlavaty A, Favrolt N, Chaumais MC, Grynblat J, Jutant EM, Lechartier B, Maurac A, Mouillot P, Palat S, Rambach L, Antigny F, Cottin V, Beltramo G, Humbert M, Khouri C, Bonniaud P, Montani D

Association of Pulmonary Hypertension With Trastuzumab Emtansine: An Analysis of French Pulmonary Hypertension Registry and WHO Pharmacovigilance Database.

Chest 2025 May;167 — 2025 May — 1468-1480