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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.g

Pulmonary fibrosis

Publications

Zhang H, Liu P, Qiao P, Zhou J, Zhao Y, Xing X, Li G

CT imaging as a prognostic indicator for patients with pulmonary injury from acute paraquat poisoning.

The British journal of radiology. 2013;86(1026):20130035

Song JW, Jeong YJ, Kim KI, Choi SJ, Lee HK, Lee KN, Manzano AC

Environmental lung diseases: clinical and imaging findings.

Clinical radiology. 2013;68(3):310-6

Lorenzen JM, Schonenberger E, Hafer C, Hoeper M, Kielstein JT

Failed rescue therapy with rapamycin after paraquat intoxication.

Clinical toxicology (Philadelphia, Pa.). 2010;48(1):84-6

Beligaswatte AM, Kularatne SA, Seneviratne AB, Wijenayake MS, Kularatne WK, Pathirage LM

An outbreak of fatal pneumonitis caused by contamination of illicit alcohol with paraquat.

Clinical toxicology (Philadelphia, Pa.). 2008;46(8):768-70

Huh JW, Hong SB, Lim CM, Do KH, Lee JS, Koh Y

Sequential radiologic and functional pulmonary changes in patients with paraquat intoxication.

International journal of occupational and environmental health. 2006;12(3):203-8

Lin JL, Liu L, Leu ML

Recovery of respiratory function in survivors with paraquat intoxication.

Archives of environmental health. 1995;50(6):432-9

Papiris SA, Maniati MA, Kyriakidis V, Constantopoulos SH

Pulmonary damage due to paraquat poisoning through skin absorption.

Respiration; international review of thoracic diseases. 1995;62(2):101-3

Matthew H, Logan A, Woodruff MF, Heard B

Paraquat poisoning--lung transplantation.

British medical journal. 1968;3(5621):759-63

Hudson M, Patel SB, Ewen SW, Smith CC, Friend JA

Paraquat induced pulmonary fibrosis in three survivors.

Thorax. 1991;46(3):201-4

Smith P, Heath D

The pathology of the lung in paraquat poisoning.

Journal of clinical pathology. Supplement (Royal College of Pathologists). 1975;9:81-93