The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

II.a

Pulmonary edema, noncardiogenic (NCPE)

Publications

Diress GM, Mohammed AS, Yesuf MH, Minda Z

A case report on acute pulmonary edema induced by adverse drug event immediately after cesarean section.

International journal of surgery case reports. 2025;128:110991

Mansour MK, Dehelia M, Hydoub YM, Kousa O, Hassan B

Oxytocin-Induced Acute Pulmonary Edema: A Case Report and Literature Review.

Cureus. 2021;13(5):e15067

Dogdu O, Yarlioglues M, Inanc T, Ardic I, Zencir C, Kaya MG

Fatal pulmonary oedema following oxytocin administration in a pregnant woman with acute myocardial infarction.

Cardiovascular toxicology. 2011;11(1):74-7

Ghai B, Vayjnath AM, Lal S

Acute pulmonary oedema following oxytocin administration: a life threatening complication.

Journal of the Indian Medical Association. 2006;104(5):261-2

Heytens L, Camu F

Pulmonary edema during cesarean section related to the use of oxytocic drugs.

Acta anaesthesiologica Belgica. 1984;35(2):155-64

Johnstone M

The cardiovascular effects of oxytocic drugs.

British journal of anaesthesia. 1972;44(8):826-34

Shahin J, Guharoy SR

Pulmonary edema possibly developing secondary to the intravenous administration of oxytocin.

Veterinary and human toxicology. 1991;33(6):587-8