The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLII.a

Alveolar hemorrhage (AH), diffuse AH (DAH)

Publications

Marak CP, Alappan N, Shim C, Guddati AK

Diffuse alveolar hemorrhage due to ketorolac tromethamine.

Pharmacology 2013;92;11-3 — 2013 — 11-3

Rubin AS, Hochhegger B, Irion KL, Marchiori E, Binukrishnan SR, Moreira JS, Zanetti G

Ketorolac tromethamine associated with diffuse pulmonary haemorrhage: high-resolution CT findings.

The British journal of radiology 2010 Jul;83;e158-60 — 2010 Jul — e158-60