The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Anaphylaxis-Anaphylactoid reaction (can be fatal)
Publications
Yarema M, Chopra P, Sivilotti MLA, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B
Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.
Journal of medical toxicology : official journal of the American College of Medical Toxicology. 2018;14(2):120-127
Adverse reactions associated with acetylcysteine.
Clinical toxicology (Philadelphia, Pa.). 2009;47(2):81-8
[Side-effects of N-acetylcysteine treatment in patients with paracetamol poisoning].
Ugeskrift for laeger. 1999;161(18):2669-72
Adverse reactions to acetylcysteine and effects of overdose.
British medical journal (Clinical research ed.). 1984;289(6439):217-9