The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Yarema M, Chopra P, Sivilotti MLA, Johnson D, Nettel-Aguirre A, Bailey B, Victorino C, Gosselin S, Purssell R, Thompson M, Spyker D, Rumack B

Anaphylactoid Reactions to Intravenous N-Acetylcysteine during Treatment for Acetaminophen Poisoning.

Journal of medical toxicology : official journal of the American College of Medical Toxicology 2018 Jun;14;120-127 — 2018 Jun — 120-127

Sandilands EA, Bateman DN

Adverse reactions associated with acetylcysteine.

Clinical toxicology (Philadelphia, Pa.) 2009 Feb;47;81-8 — 2009 Feb — 81-8

Schmidt LE, Dalhoff KP

[Side-effects of N-acetylcysteine treatment in patients with paracetamol poisoning].

Ugeskrift for laeger 1999 May 03;161;2669-72 — 1999 May 03 — 2669-72

Mant TG, Tempowski JH, Volans GN, Talbot JC

Adverse reactions to acetylcysteine and effects of overdose.

British medical journal (Clinical research ed.) 1984 Jul 28;289;217-9 — 1984 Jul 28 — 217-9