The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XLIV.d

Laryngeal disorder-Laryngeal nerve palsy (dysphonia, hoarseness)

Publications

Shen L, Xu L, Wang Y, Wu Y, Duan X

Penpulimab-induced complete atrioventricular block in a patient with metastatic renal cancer.

HeartRhythm case reports 2023 Jul;9;451-455 — 2023 Jul — 451-455

Tay SY, Foster J, Heczey A, Sitton M

Pediatric Oncology Patients With Vincristine-Induced Recurrent Laryngeal Nerve Palsy: Two Case Reports and a Brief Review of Literature.

Ear, nose, & throat journal 2021 Dec;100;NP459-NP463 — 2021 Dec — NP459-NP463