The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Transfusion-related acute lung injury (TRALI) (May cause ARDS)
A leading cause of transfusion-related mortality
Can occur at any age, including in neonates
Diuretics may aggravate this form of pulmonary injury
Publications
Transfusion-related acute lung injury-associated HNA-3a antibodies recognize complex determinants on choline transporter-like protein 2.
Transfusion. 2014;54(12):3208-15
Residual plasma in red blood cells and transfusion-related acute lung injury.
Transfusion. 2014;54(10):2425-30
Acute respiratory failure during routine blood transfusion: a case report and review of the literature.
The Journal of emergency medicine. 2014;46(3):341-4
Transfusion-related acute lung injury: a clinical review.
Lancet (London, England). 2013;382(9896):984-94
Perioperative transfusion-related acute lung injury: a retrospective analysis.
Acta anaesthesiologica Taiwanica : official journal of the Taiwan Society of Anesthesiologists. 2012;50(3):96-100
Schmidt AE, Adamski J, Education Committee of the Academy of Clinical Laboratory Physicians and Scientists
Pathology consultation on transfusion-related acute lung injury (TRALI).
American journal of clinical pathology. 2012;138(4):498-503
Post transfusion lung injury in the neonatal population.
Journal of perinatology : official journal of the California Perinatal Association. 2013;33(4):292-6
Pulmonary complications of transfused blood components.
Critical care nursing clinics of North America. 2012;24(3):403-18
Vlaar AP, Hofstra JJ, Determann RM, Veelo DP, Paulus F, Levi M, Zeerleder S, Vroom MB, Schultz MJ, Juffermans NP
Transfusion-related acute lung injury in cardiac surgery patients is characterized by pulmonary inflammation and coagulopathy: a prospective nested case-control study.
Critical care medicine. 2012;40(10):2813-20
Blood donors implicated in transfusion-related acute lung injury with patient-specific HLA antibodies are more broadly sensitized to HLA antigens compared to other blood donors.
Transfusion. 2013;53(3):518-25
Transfusion-related acute lung injury: Current understanding and preventive strategies.
Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine. 2012;19(3):117-24
Reducing transfusion-related acute lung injury risk: evidence for and approaches to transfusion-related acute lung injury mitigation.
Transfusion medicine reviews. 2012;26(4):305-20
Lucas G, Win N, Calvert A, Green A, Griffin E, Bendukidze N, Hopkins M, Browne T, Poles A, Chapman C, Massey E
Reducing the incidence of TRALI in the UK: the results of screening for donor leucocyte antibodies and the development of national guidelines.
Vox sanguinis. 2012;103(1):10-7
Toy P, Gajic O, Bacchetti P, Looney MR, Gropper MA, Hubmayr R, Lowell CA, Norris PJ, Murphy EL, Weiskopf RB, Wilson G, Koenigsberg M, Lee D, Schuller R, Wu P, Grimes B, Gandhi MJ, Winters JL, Mair D, Hirschler N, Sanchez Rosen R, Matthay MA, TRALI Study G
Transfusion-related acute lung injury: incidence and risk factors.
Blood. 2012;119(7):1757-67
TRALI is due to pulmonary venule damage from leucocytes with cholesterol crystal formation.
Vox sanguinis. 2010;98(2):130-7
Transfusion-related acute lung injury: current concepts for the clinician.
Anesthesia and analgesia. 2009;108(3):770-6
Pulmonary consequences of transfusion: TRALI and TACO.
Transfusion and apheresis science : official journal of the World Apheresis Association : official journal of the European Society for Haemapheresis. 2006;34(3):243-4
Understanding the consequences of transfusion-related acute lung injury.
Chest. 2005;128(5 Suppl 2):598S-604S
Transfusion-related acute lung injury.
Mayo Clinic proceedings. 2005;80(6):766-70
Transfusion-related acute lung injury: a review.
Chest. 2004;126(1):249-58