The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.d

Organizing pneumonia pattern (an area or areas of consolidation on imaging)

Publications

Gans A, Verrengia EP, Ricchiuti E, Leva S, Brajkovic S, Colombo D, Mazzone A, Prelle A

Ocrelizumab-associated cryptogenic organizing pneumonia in multiple sclerosis: Two case reports and comprehensive literature review.

Multiple sclerosis (Houndmills, Basingstoke, England). 2025;31(6):740-743

Aysan N, Köybaşı G, Satıcı C, Demirkol MA, Arpınar Yiğitbaş B, Arpaçağ Koşar AF

Organizing pneumonia following ocrelizumab use in a patient with multiple sclerosis: A case report.

Tuberkuloz ve toraks. 2023;71(1):107-111