The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.y

Progression, acceleration or exacerbation of preexisting ILD/fibrosis

Publications

Mohamad R, Hallak R, Bou Akl I, Bou Fakhreddine H

A Lethal Case of Acute Exacerbation of Rheumatoid Arthritis - Related Interstitial Lung Disease Induced by the COVID Vaccine.

Respiratory medicine case reports. 2024;48:101959

Ishioka Y, Makiguchi T, Itoga M, Tanaka H, Taima K, Goto S, Tasaka S

Acute Exacerbation of Interstitial Lung Disease After SARS-CoV-2 Vaccination: A Case Series.

Chest. 2022;162(6):e311-e316

Park JY, Kim JH, Park S, Hwang YI, Kim HI, Jang SH, Jung KS, Kim YK, Kim HA, Lee IJ

Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review.

The Korean journal of internal medicine. 2022;37(5):989-1001

Bocchino M, Rea G, Buonocore A, Lieto R, Mazzocca A, Di Domenico A, Stanziola AA

Combination of acute exacerbation of idiopathic nonspecific interstitial pneumonia and pulmonary embolism after booster anti-COVID-19 vaccination.

Respiratory medicine case reports. 2022;38:101674

Sgalla G, Magrì T, Lerede M, Comes A, Richeldi L

COVID-19 Vaccine in Patients with Exacerbation of Idiopathic Pulmonary Fibrosis.

American journal of respiratory and critical care medicine. 2022;206(2):219-221

Bando T, Takei R, Mutoh Y, Sasano H, Yamano Y, Yokoyama T, Matsuda T, Kataoka K, Kimura T, Kondoh Y

Acute exacerbation of idiopathic pulmonary fibrosis after SARS-CoV-2 vaccination.

The European respiratory journal. 2022;59(3)

Ghincea A, Ryu C, Herzog EL

An Acute Exacerbation of Idiopathic Pulmonary Fibrosis After BNT162b2 mRNA COVID-19 Vaccination: A Case Report.

Chest. 2022;161(2):e71-e73