The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Organizing pneumonia pattern (an area or areas of consolidation on imaging)
ILD cases with prior recent exposure to amiodarone raise the possibility of delayed-onset amiodarone pulmonary toxicity. Cases with concomitant statins (PMID 25846536) raise the possibility of statin-induced ILD
Publications
Hernández Voth AR, Catalán JS, Benavides Mañas PD, Avila Martínez RJ, Peñalver Paolini CL, Díaz de Atauri Rodríguez MJ
A 73-year-old man with interstitial lung disease due to dronedarone.
American journal of respiratory and critical care medicine 2012 Jul 15;186;201-2 — 2012 Jul 15 — 201-2
Fatal lung toxic effects related to dronedarone use.
Archives of internal medicine 2012 Mar 26;172;516-7 — 2012 Mar 26 — 516-7