The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

L.b

Chest pain (acute or subacute), lone or prominent

Publications

Sara JD, Kaur J, Khodadadi R, Rehman M, Lobo R, Chakrabarti S, Herrmann J, Lerman A, Grothey A

5-fluorouracil and cardiotoxicity: a review.

Therapeutic advances in medical oncology 2018;10;1758835918780140 — 2018 — 1758835918780140

Timour Q, Lombard-Bohas C, Slim R, Barel C, Bui-Xuan B, Tabib A, Bricca G, Malonne H, Vial T, Iordescu D, Descotes J

[Cardiotoxicity of 5-fluorouracil: report of 6 cases].

Therapie 2002 May-Jun;57;302-6 — 2002 May-Jun — 302-6

McGlinchey PG, Webb ST, Campbell NP

5-fluorouracil-induced cardiotoxicity mimicking myocardial infarction: a case report.

BMC cardiovascular disorders 2001;1;3 — 2001 — 3

Gradishar WJ, Vokes EE

5-Fluorouracil cardiotoxicity: a critical review.

Annals of oncology : official journal of the European Society for Medical Oncology 1990 Nov;1;409-14 — 1990 Nov — 409-14