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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.c

Pericardial effusion (w/wo tamponade)

Publications

Ferrusquía J, Pérez-Martínez I, Gómez de la Torre R, Fernández-Almira ML, de Francisco R, Rodrigo L, Riestra S

Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity.

World journal of gastroenterology. 2015;21(13):4069-77

Hermida JS, Six I, Jarry G

Drug-induced pericarditis mimicking Brugada syndrome.

Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology. 2007;9(1):66-8

Waite RA, Malinowski JM

Possible mesalamine-induced pericarditis: case report and literature review.

Pharmacotherapy. 2002;22(3):391-4

Gujral N, Friedenberg F, Friedenberg J, Gabriel G, Kotler M, Levine G

Pleuropericarditis related to the use of mesalamine.

Digestive diseases and sciences. 1996;41(3):624-6

Loizeau E

[Ulcerative colitis and pericarditis. The role of mesalazine hypersensitivity].

Revue medicale de la Suisse romande. 1995;115(11):935-8

Desmeules J, Vogt N, Loizeau S, Angelillo-Scherrer A, Dayer P

[Recurrent pericarditis induced by mesalazine (5-ASA)].

Therapie. 1994;49(4):359-61