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The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Nasim S, Zaalouk TM, Bocus A, Kerols M

Late-Onset Mesalazine-Induced Eosinophilic Pneumonitis Presenting as Non-Resolving Pneumonia: A Diagnostic Pitfall in Ulcerative Colitis.

Clinical case reports. 2026;14(2):e72029

Li S, Fang M, Guo H, Yu T, Wang J, Li W, Huang Y, Wang X, Wu R

Eosinophilic pulmonary disease with ulcerative colitis: A case report.

Medicine. 2024;103(17):e37851

Pereira FM, Marques C, Boncoraglio T, Esteves J, Silva M, Braga J, Ribeiro M

Mesalazine-induced Hypersensitivity Pneumonitis.

European journal of case reports in internal medicine. 2021;8(1):002194

Park M, Lee J, Kang SB, Park Y

Recurrent Eosinophilic Pneumonia Associated with Mesalazine Suppository in a Patient with Ulcerative Colitis.

The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi. 2019;73(4):225-229

Yeo J, Woo HS, Lee SM, Kim YJ, Kwon KA, Park DK, Kim JH, Kim KO, Chung JW

Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide.

Intestinal research. 2017;15(4):529-534

Gupta A, Gulati S

Mesalamine induced eosinophilic pneumonia.

Respiratory medicine case reports. 2017;21:116-117

Ferrusquía J, Pérez-Martínez I, Gómez de la Torre R, Fernández-Almira ML, de Francisco R, Rodrigo L, Riestra S

Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity.

World journal of gastroenterology. 2015;21(13):4069-77

Michy B, Raymond S, Graffin B

[Organizing pneumonia during treatment with mesalazine].

Revue des maladies respiratoires. 2014;31(1):70-7

Caccaro R, Savarino E, D'Incà R, Sturniolo GC

Noninfectious interstitial lung disease during infliximab therapy: case report and literature review.

World journal of gastroenterology. 2013;19(32):5377-80

Kim JH, Lee JH, Koh ES, Park SW, Jang AS, Kim D, Park CS

Acute eosinophilic pneumonia related to a mesalazine suppository.

Asia Pacific allergy. 2013;3(2):136-9

Fayaz M, Sultan A, Nawaz M, Sultan N

Mesalazine-induced eosinophilic variant of Wegener's granulomatosis in an ulcerative colitis patient.

Journal of Ayub Medical College, Abbottabad : JAMC. 2009;21(4):171-3

Saltzman K, Rossoff LJ, Gouda H, Tongia S

Mesalamine-induced unilateral eosinophilic pneumonia.

AJR. American journal of roentgenology. 2001;177(1):257

Zamir D, Weizman J, Zamir C, Fireman Z, Weiner P

[Mesalamine-induced hypersensitivity pneumonitis].

Harefuah. 1999;137(1-2):28-30, 87, 86

Lázaro MT, García-Tejero MT, Díaz-Lobato S

Mesalamine-induced lung disease.

Archives of internal medicine. 1997;157(4):462

Bitton A, Peppercorn MA, Hanrahan JP, Upton MP

Mesalamine-induced lung toxicity.

The American journal of gastroenterology. 1996;91(5):1039-40

Camus P, Piard F, Ashcroft T, Gal AA, Colby TV

The lung in inflammatory bowel disease.

Medicine. 1993;72(3):151-83

Takahashi N, Aizawa H, Takata S, Matsumoto K, Koto H, Inoue H, Hara N

Acute interstitial pneumonitis induced by carbamazepine.

The European respiratory journal. 1993;6(9):1409-11

Honeybourne D

Mesalazine toxicity.

BMJ (Clinical research ed.). 1994;308(6927):533-4