The Drug-Induced Respiratory Disease Website and App
Frequency - Incidence
Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases
Evidence level/grade
Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic
Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)
Publications
Late-Onset Mesalazine-Induced Eosinophilic Pneumonitis Presenting as Non-Resolving Pneumonia: A Diagnostic Pitfall in Ulcerative Colitis.
Clinical case reports 2026 Feb;14;e72029 — 2026 Feb
Eosinophilic pulmonary disease with ulcerative colitis: A case report.
Medicine 2024 Apr 26;103;e37851 — 2024 Apr 26 — e37851
Mesalazine-induced Hypersensitivity Pneumonitis.
European journal of case reports in internal medicine 2021;8;002194 — 2021 — 002194
Recurrent Eosinophilic Pneumonia Associated with Mesalazine Suppository in a Patient with Ulcerative Colitis.
The Korean journal of gastroenterology = Taehan Sohwagi Hakhoe chi 2019 Apr 25;73;225-229 — 2019 Apr 25 — 225-229
Drug-induced eosinophilic pneumonia in a patient with Crohn's disease: diagnosis and treatment using fraction of exhaled nitric oxide.
Intestinal research 2017 Oct;15;529-534 — 2017 Oct — 529-534
Mesalamine induced eosinophilic pneumonia.
Respiratory medicine case reports 2017;21;116-117 — 2017 — 116-117
Ferrusquía J, Pérez-Martínez I, Gómez de la Torre R, Fernández-Almira ML, de Francisco R, Rodrigo L, Riestra S
Gastroenterology case report of mesalazine-induced cardiopulmonary hypersensitivity.
World journal of gastroenterology 2015 Apr 07;21;4069-77 — 2015 Apr 07 — 4069-77
[Organizing pneumonia during treatment with mesalazine].
Revue des maladies respiratoires 2014 Jan;31;70-7 — 2014 Jan — 70-7
Noninfectious interstitial lung disease during infliximab therapy: case report and literature review.
World journal of gastroenterology 2013 Aug 28;19;5377-80 — 2013 Aug 28 — 5377-80
Acute eosinophilic pneumonia related to a mesalazine suppository.
Asia Pacific allergy 2013 Apr;3;136-9 — 2013 Apr — 136-9
Mesalazine-induced eosinophilic variant of Wegener's granulomatosis in an ulcerative colitis patient.
Journal of Ayub Medical College, Abbottabad : JAMC 2009 Oct-Dec;21;171-3 — 2009 Oct-Dec — 171-3
Mesalamine-induced unilateral eosinophilic pneumonia.
AJR. American journal of roentgenology 2001 Jul;177;257 — 2001 Jul — 257
[Mesalamine-induced hypersensitivity pneumonitis].
Harefuah 1999 Jul;137;28-30, 87, 86 — 1999 Jul — 28-30, 87, 86
Mesalamine-induced lung disease.
Archives of internal medicine 1997 Feb 24;157;462 — 1997 Feb 24 — 462
Mesalamine-induced lung toxicity.
The American journal of gastroenterology 1996 May;91;1039-40 — 1996 May — 1039-40
The lung in inflammatory bowel disease.
Medicine 1993 May;72;151-83 — 1993 May — 151-83
Acute interstitial pneumonitis induced by carbamazepine.
The European respiratory journal 1993 Oct;6;1409-11 — 1993 Oct — 1409-11
Mesalazine toxicity.
BMJ (Clinical research ed.) 1994 Feb 19;308;533-4 — 1994 Feb 19 — 533-4