The Drug-Induced Respiratory Disease Website and App

Mesalazine-Mesalamine-5-aminosalicylic acid-5-ASA

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.a

Pneumonitis (ILD), acute and/or severe (may produce the ARDS pattern)

Publications

Huang PH, Kuo CJ, Lin CW, Cheng YM, Hu HC, Lin CY, Su MY, Chiu CT

Mesalazine-related lung disease in a patient with ulcerative colitis: A case report.

Medicine 2018 Nov;97;e13242 — 2018 Nov — e13242

Facchini S, Candusso M, Zennaro F, Ventura A

Clinical quiz. 5-ASA hypersensitivity lung disease.

Journal of pediatric gastroenterology and nutrition 1999 Sep;29;349,357 — 1999 Sep — 349,357