The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Suzuki T, Furuta H, Naganawa M, Hayashi K, Kiyotoshi H, Ohta C, Ninomiya S

COVID-19 Vaccine-Induced Severe Pneumonitis.

Respirology case reports. 2025;13(8):e70274

Park JY, Kim JH, Park S, Hwang YI, Kim HI, Jang SH, Jung KS, Kim YK, Kim HA, Lee IJ

Clinical characteristics of patients with COVID-19 vaccine-related pneumonitis: a case series and literature review.

The Korean journal of internal medicine. 2022;37(5):989-1001

Taverner JVB, Robertson JG

A case of interstitial lung disease following Oxford-AstraZeneca COVID-19 vaccination.

Internal medicine journal. 2022;52(7):1276-1277

Bando T, Takei R, Mutoh Y, Sasano H, Yamano Y, Yokoyama T, Matsuda T, Kataoka K, Kimura T, Kondoh Y

Acute exacerbation of idiopathic pulmonary fibrosis after SARS-CoV-2 vaccination.

The European respiratory journal. 2022;59(3)

Stoyanov A, Thompson G, Lee M, Katelaris C

Delayed hypersensitivity to the Comirnaty coronavirus disease 2019 vaccine presenting with pneumonitis and rash.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2022;128(3):321-322

Shimizu T, Watanabe S, Yoneda T, Kinoshita M, Terada N, Kobayashi T, Gohara K, Tsuji T, Nakatsumi H, Tambo Y, Ohkura N, Abo M, Hara J, Sone T, Kimura H, Kasahara K

Interstitial pneumonitis after COVID-19 vaccination: A report of three cases.

Allergology international : official journal of the Japanese Society of Allergology. 2022;71(2):251-253

Park JY, Kim JH, Lee IJ, Kim HI, Park S, Hwang YI, Jang SH, Jung KS

COVID-19 vaccine-related interstitial lung disease: a case study.

Thorax. 2022;77(1):102-104