The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (interstitial lung disease/ILD)

Publications

Waters MJ, Sukumaran S, Karapetis CS

Pemetrexed-Induced Interstitial Pneumonitis: A Case Study and Literature Review.

World journal of oncology. 2014;5(5-6):232-236

Tomii K, Kato T, Takahashi M, Noma S, Kobashi Y, Enatsu S, Okubo S, Kobayashi N, Kudoh S

Pemetrexed-related interstitial lung disease reported from post marketing surveillance (malignant pleural mesothelioma/non-small cell lung cancer).

Japanese journal of clinical oncology. 2017;47(4):350-356

Dhakal B, Singh V, Shrestha A, Rao A, Choong N

Pemetrexed induced pneumonitis.

Clinics and practice. 2011;1(4):e106

Kim KH, Song SY, Lim KH, Han SS, Kim SH, Cho JH, Park CW, Lee S, Lee HY

Interstitial Pneumonitis after Treatment with Pemetrexed for Non-small Cell Lung Cancer.

Cancer research and treatment. 2013;45(1):74-7

Hochstrasser A, Benz G, Joerger M, Templeton A, Brutsche M, Früh M

Interstitial pneumonitis after treatment with pemetrexed: a rare event?

Chemotherapy. 2012;58(1):84-8

Breuer S, Nechushtan H

Pemetrexed-induced lung toxicity: a case report.

Clinical oncology (Royal College of Radiologists (Great Britain)). 2012;24(1):76-7

Loriot Y, Ferte C, Gomez-Roca C, Moldovan C, Bahleda R, Wislez M, Cadranel J, Soria JC

Pemetrexed-induced pneumonitis: a case report.

Clinical lung cancer. 2009;10(5):364-6