The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.d

Myocarditis (can be fulminant)

See PMID 34514306

Publications

Bouchaala A, Nguadi J, Benhlima A, Arfaoui M, Elhamzaoui H, Alilou M

Post-vaccine COVID-19 acute myocarditis: case reports and literature review.

The Pan African medical journal 2023;44;192 — 2023 — 192

Goddard K, Lewis N, Fireman B, Weintraub E, Shimabukuro T, Zerbo O, Boyce TG, Oster ME, Hanson KE, Donahue JG, Ross P, Naleway A, Nelson JC, Lewin B, Glanz JM, Williams JTB, Kharbanda EO, Katherine Yih W, Klein NP

Risk of myocarditis and pericarditis following BNT162b2 and mRNA-1273 COVID-19 vaccination.

Vaccine 2022 Aug 19;40;5153-5159 — 2022 Aug 19 — 5153-5159

Kim SH, Lee SY, Kim GY, Oh JS, Kim J, Chun KJ, Ju MH, Lee CH, Song YJ, Na JY

A Case of Heart Transplantation for Fulminant Myocarditis After ChAdOx1 nCoV-19 Vaccination.

Journal of Korean medical science 2022 Apr 04;37;e104 — 2022 Apr 04 — e104

Gill J, Mallari AJP, Zahra F

Transient Myopericarditis Following Vaccination for COVID-19.

Journal of medical cases 2022 Feb;13;80-84 — 2022 Feb — 80-84

Parmar K, Mekraksakit P, Del Rio-Pertuz G, Sethi P, Motes A, Hughes M, Wischmeyer J, Carbajal L, Sosa EA

Myocarditis following COVID-19 mRNA vaccination.

Proceedings (Baylor University. Medical Center) 2022;35;209-213 — 2022 — 209-213

Goyal M, Ray I, Mascarenhas D, Kunal S, Sachdeva RA, Ish P

Myocarditis post SARS-CoV-2 vaccination: a systematic review.

QJM : monthly journal of the Association of Physicians 2022 Mar 03;; — 2022 Mar 03

Lee ASY, Balakrishnan IDD, Khoo CY, Ng CT, Loh JKX, Chan LL, Teo LLY, Sim DKL

Myocarditis Following COVID-19 Vaccination: A Systematic Review (October 2020-October 2021).

Heart, lung & circulation 2022 Feb 25;; — 2022 Feb 25

Bengel CP, Kacapor R

A report of two cases of myocarditis following mRNA coronavirus disease 2019 vaccination.

European heart journal. Case reports 2022 Jan;6;ytac004 — 2022 Jan — ytac004

Oka A, Sudo Y, Miyoshi T, Ozaki M, Kimura Y, Takagi W, Ugawa S, Okada T, Nosaka K, Doi M

Fulminant myocarditis after the second dose of COVID-19 mRNA vaccination.

Clinical case reports 2022 Feb;10;e05378 — 2022 Feb — e05378

Cui G, Li R, Zhao C, Wang DW

Case Report: COVID-19 Vaccination Associated Fulminant Myocarditis.

Frontiers in cardiovascular medicine 2021;8;769616 — 2021 — 769616

Naghashzadeh F, Shafaghi S, Dorudinia A, Naji SA, Marjani M, Amin A, Mohamadifar A, Noorali S, Kashani BS

Myocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report.

ESC heart failure 2022 Feb 01;; — 2022 Feb 01

Chachar TS, Yousuf N, Sulaibikh L, Abdulqader F, Alqahtani M

First Report of Acute Myocarditis Post-Pfizer-BioNTech COVID-19 Vaccination in the Kingdom of Bahrain.

Cureus 2021 Dec;13;e20313 — 2021 Dec

Tailor PD, Feighery AM, El-Sabawi B, Prasad A

Case report: acute myocarditis following the second dose of mRNA-1273 SARS-CoV-2 vaccine.

European heart journal. Case reports 2021 Aug;5;ytab319 — 2021 Aug — ytab319

Abbate A, Gavin J, Madanchi N, Kim C, Shah PR, Klein K, Boatman J, Roberts C, Patel S, Danielides S

Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients.

International journal of cardiology 2021 Aug 18;; — 2021 Aug 18

Bozkurt B, Kamat I, Hotez PJ

Myocarditis with COVID-19 mRNA Vaccines.

Circulation 2021 Jul 20;; — 2021 Jul 20

Vidula MK, Ambrose M, Glassberg H, Chokshi N, Chen T, Ferrari VA, Han Y

Myocarditis and Other Cardiovascular Complications of the mRNA-Based COVID-19 Vaccines.

Cureus 2021 Jun;13;e15576 — 2021 Jun — e15576

Singh B, Kaur P, Cedeno L, Brahimi T, Patel P, Virk H, Shamoon F, Bikkina M

COVID-19 mRNA Vaccine and Myocarditis.

European journal of case reports in internal medicine 2021;8;002681 — 2021 — 002681

Habib MB, Hamamyh T, Elyas A, Altermanini M, Elhassan M

Acute myocarditis following administration of BNT162b2 vaccine.

IDCases 2021;25;e01197 — 2021 — e01197

Shay DK, Shimabukuro TT, DeStefano F

Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines.

JAMA cardiology 2021 Jun 29;; — 2021 Jun 29

Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.

JAMA cardiology 2021 Jun 29;; — 2021 Jun 29

Wise J

Covid-19: Should we be worried about reports of myocarditis and pericarditis after mRNA vaccines?

BMJ (Clinical research ed.) 2021 Jun 24;373;n1635 — 2021 Jun 24 — n1635

Larson KF, Ammirati E, Adler ED, Cooper LT, Hong KN, Saponara G, Couri D, Cereda A, Procopio A, Cavalotti C, Oliva F, Sanna T, Ciconte VA, Onyango G, Holmes DR, Borgeson DD

Myocarditis after BNT162b2 and mRNA-1273 Vaccination.

Circulation 2021 Jun 16;; — 2021 Jun 16