The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

XII.d

Myocarditis (can be fulminant)

See PMID 34514306

Publications

Bouchaala A, Nguadi J, Benhlima A, Arfaoui M, Elhamzaoui H, Alilou M

Post-vaccine COVID-19 acute myocarditis: case reports and literature review.

The Pan African medical journal. 2023;44:192

Goddard K, Lewis N, Fireman B, Weintraub E, Shimabukuro T, Zerbo O, Boyce TG, Oster ME, Hanson KE, Donahue JG, Ross P, Naleway A, Nelson JC, Lewin B, Glanz JM, Williams JTB, Kharbanda EO, Katherine Yih W, Klein NP

Risk of myocarditis and pericarditis following BNT162b2 and mRNA-1273 COVID-19 vaccination.

Vaccine. 2022;40(35):5153-5159

Kim SH, Lee SY, Kim GY, Oh JS, Kim J, Chun KJ, Ju MH, Lee CH, Song YJ, Na JY

A Case of Heart Transplantation for Fulminant Myocarditis After ChAdOx1 nCoV-19 Vaccination.

Journal of Korean medical science. 2022;37(13):e104

Gill J, Mallari AJP, Zahra F

Transient Myopericarditis Following Vaccination for COVID-19.

Journal of medical cases. 2022;13(2):80-84

Parmar K, Mekraksakit P, Del Rio-Pertuz G, Sethi P, Motes A, Hughes M, Wischmeyer J, Carbajal L, Sosa EA

Myocarditis following COVID-19 mRNA vaccination.

Proceedings (Baylor University. Medical Center). 2022;35(2):209-213

Goyal M, Ray I, Mascarenhas D, Kunal S, Sachdeva RA, Ish P

Myocarditis post-SARS-CoV-2 vaccination: a systematic review.

QJM : monthly journal of the Association of Physicians. 2023;116(1):7-25

Lee ASY, Balakrishnan IDD, Khoo CY, Ng CT, Loh JKX, Chan LL, Teo LLY, Sim DKL

Myocarditis Following COVID-19 Vaccination: A Systematic Review (October 2020-October 2021).

Heart, lung & circulation. 2022;31(6):757-765

Bengel CP, Kacapor R

A report of two cases of myocarditis following mRNA coronavirus disease 2019 vaccination.

European heart journal. Case reports. 2022;6(1):ytac004

Oka A, Sudo Y, Miyoshi T, Ozaki M, Kimura Y, Takagi W, Ugawa S, Okada T, Nosaka K, Doi M

Fulminant myocarditis after the second dose of COVID-19 mRNA vaccination.

Clinical case reports. 2022;10(2):e05378

Cui G, Li R, Zhao C, Wang DW

Case Report: COVID-19 Vaccination Associated Fulminant Myocarditis.

Frontiers in cardiovascular medicine. 2021;8:769616

Naghashzadeh F, Shafaghi S, Dorudinia A, Naji SA, Marjani M, Amin A, Mohamadifar A, Noorali S, Kashani BS

Myocarditis following rAd26 and rAd5 vector-based COVID-19 vaccine: case report.

ESC heart failure. 2022;9(2):1483-1486

Chachar TS, Yousuf N, Sulaibikh L, Abdulqader F, Alqahtani M

First Report of Acute Myocarditis Post-Pfizer-BioNTech COVID-19 Vaccination in the Kingdom of Bahrain.

Cureus. 2021;13(12):e20313

Tailor PD, Feighery AM, El-Sabawi B, Prasad A

Case report: acute myocarditis following the second dose of mRNA-1273 SARS-CoV-2 vaccine.

European heart journal. Case reports. 2021;5(8):ytab319

Abbate A, Gavin J, Madanchi N, Kim C, Shah PR, Klein K, Boatman J, Roberts C, Patel S, Danielides S

Fulminant myocarditis and systemic hyperinflammation temporally associated with BNT162b2 mRNA COVID-19 vaccination in two patients.

International journal of cardiology. 2021;340:119-121

Bozkurt B, Kamat I, Hotez PJ

Myocarditis With COVID-19 mRNA Vaccines.

Circulation. 2021;144(6):471-484

Vidula MK, Ambrose M, Glassberg H, Chokshi N, Chen T, Ferrari VA, Han Y

Myocarditis and Other Cardiovascular Complications of the mRNA-Based COVID-19 Vaccines.

Cureus. 2021;13(6):e15576

Singh B, Kaur P, Cedeno L, Brahimi T, Patel P, Virk H, Shamoon F, Bikkina M

COVID-19 mRNA Vaccine and Myocarditis.

European journal of case reports in internal medicine. 2021;8(7):002681

Habib MB, Hamamyh T, Elyas A, Altermanini M, Elhassan M

Acute myocarditis following administration of BNT162b2 vaccine.

IDCases. 2021;25:e01197

Shay DK, Shimabukuro TT, DeStefano F

Myocarditis Occurring After Immunization With mRNA-Based COVID-19 Vaccines.

JAMA cardiology. 2021;6(10):1115-1117

Kim HW, Jenista ER, Wendell DC, Azevedo CF, Campbell MJ, Darty SN, Parker MA, Kim RJ

Patients With Acute Myocarditis Following mRNA COVID-19 Vaccination.

JAMA cardiology. 2021;6(10):1196-1201

Wise J

Covid-19: Should we be worried about reports of myocarditis and pericarditis after mRNA vaccines?

BMJ (Clinical research ed.). 2021;373:n1635

Larson KF, Ammirati E, Adler ED, Cooper LT Jr, Hong KN, Saponara G, Couri D, Cereda A, Procopio A, Cavalotti C, Oliva F, Sanna T, Ciconte VA, Onyango G, Holmes DR, Borgeson DD

Myocarditis After BNT162b2 and mRNA-1273 Vaccination.

Circulation. 2021;144(6):506-508