The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.aw

Visceral angioedema (can cause relapsing abdominal pain)

Can cause remitting abdominal pain (PMID 42226836)

Publications

Sutton S, Paulson J

Diagnosis of Lisinopril-Induced Small Bowel Angioedema After a Seven-Year Diagnostic Journey: A Case Report With Patient Perspective.

Cureus 2026 Apr;18;e108019 — 2026 Apr

Squillante MD, Trujillo A, Norton J, Bansal S, Dragoo D

ACE Inhibitor Induced Isolated Angioedema of the Small Bowel: A Rare Complication of a Common Medication.

Case reports in emergency medicine 2021;2021;8853755 — 2021 — 8853755