The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

X.f

Anaphylaxis-Anaphylactoid reaction (can be fatal)

Publications

Teufelberger AR, Dan AR, Irmler L, Wolf P, Kränke B

COVID-19 vaccines: anaphylaxis and anxiety : A case study from an allergy unit.

Wiener klinische Wochenschrift. 2024;136(21-22):590-597

Luxi N, Giovanazzi A, Arcolaci A, Bonadonna P, Crivellaro MA, Cutroneo PM, Ferrajolo C, Furci F, Guidolin L, Moretti U, Olivieri E, Petrelli G, Zanoni G, Senna G, Trifirò G

Allergic Reactions to COVID-19 Vaccines: Risk Factors, Frequency, Mechanisms and Management.

BioDrugs : clinical immunotherapeutics, biopharmaceuticals and gene therapy. 2022;36(4):443-458

Armstrong L, Maguire N

A Case Report of Prolonged Anaphylaxis after COVID-19 Vaccine.

Clinical practice and cases in emergency medicine. 2022;6(1):21-24

Pitlick MM, Park MA, Gonzalez-Estrada A, Chiarella SE

Biphasic anaphylaxis after first dose of messenger RNA coronavirus disease 2019 vaccine with positive polysorbate 80 skin testing result.

Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology. 2021;127(4):498-499

Tanno LK, Castells M, Caminati M, Senna G, Demoly P

Anaphylaxis and Coronavirus Disease 2019 vaccine: a danger relationship?

Current opinion in allergy and clinical immunology. 2021;21(5):411-417

Krantz MS, Liu Y, Phillips EJ, Stone CA Jr

COVID-19 vaccine anaphylaxis: PEG or not?

Allergy. 2021;76(6):1934-1937

Bellomo RG, Gallenga CE, Caraffa A, Tetè G, Ronconi G, Conti P

Anaphylaxis is a rare reaction in COVID-19 vaccination.

Journal of biological regulators and homeostatic agents. 2021;35(3):839-842

Sampath V, Rabinowitz G, Shah M, Jain S, Diamant Z, Jesenak M, Rabin R, Vieths S, Agache I, Akdis M, Barber D, Breiteneder H, Chinthrajah S, Chivato T, Collins W, Eiwegger T, Fast K, Fokkens W, O'Hehir RE, Ollert M, O'Mahony L, Palomares O, Pfaar O, Riggi

Vaccines and allergic reactions: The past, the current COVID-19 pandemic, and future perspectives.

Allergy. 2021;76(6):1640-1660

Bousquet J, Agache I, Blain H, Jutel M, Ventura MT, Worm M, Del Giacco S, Benetos A, Bilo BM, Czarlewski W, Abdul Latiff AH, Al-Ahmad M, Angier E, Annesi-Maesano I, Atanaskovic-Markovic M, Bachert C, Barbaud A, Bedbrook A, Bennoor KS, Berghea EC, Bindslev

Management of anaphylaxis due to COVID-19 vaccines in the elderly.

Allergy. 2021;76(10):2952-2964

Cabanillas B, Akdis CA, Novak N

Allergic reactions to the first COVID-19 vaccine: A potential role of polyethylene glycol?

Allergy. 2021;76(6):1617-1618