The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

LI.n

Cardiac arrhythmias or dysrhythmias (AF, VT, VF, TdP)

Publications

Oscanoa TJ, Vidal X, Kanters JK, Romero-Ortuno R

Frequency of Long QT in Patients with SARS-CoV-2 Infection Treated with Hydroxychloroquine: A Meta-analysis.

International journal of antimicrobial agents 2020 Dec;56;106212 — 2020 Dec — 106212

McBeth PB, Missirlis PI, Brar H, Dhingra V

Novel Therapies for Myocardial Irritability following Extreme Hydroxychloroquine Toxicity.

Case reports in emergency medicine 2015;2015;692948 — 2015 — 692948