The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.b

Pneumonitis (ILD), acute and/or severe (may cause ARDS)

Publications

Balzarini L, Mancini C, Marvisi M

A fatal case of acute interstitial pneumonia (AIP) in a woman affected by glioblastoma.

Current drug safety 2014 Mar;9;73-6 — 2014 Mar — 73-6

Guilleminault L, Carré P, de Luca K, Beau Salinas F, Autret-Leca E, Narciso B, Diot P

[Alveolo-interstitial pneumonia due to Temozolamide].

Revue des maladies respiratoires 2008 Sep;25;880-4 — 2008 Sep — 880-4