The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Seijari MN, Khan F, Zamani T, Mallick S, Affas MN, Beerman S

The double-edged sword of daptomycin: a case of daptomycin-induced eosinophilic pneumonia.

Oxford medical case reports. 2026;2026(8):omag146

Utley LM, Larsen S, Goldberg T, Barjasteh T

Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia.

BMJ case reports. 2025;18(7)

Shakour H, Mumtaz R, Abu-Samra AG

A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19.

Cureus. 2025;17(1):e77736

Ayala Torres JD Sr, Noreña B, Suarez Poveda AT

Eosinophilic Pneumonia Induced by Daptomycin.

Cureus. 2024;16(2):e55095

Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L

Daptomycin-Induced Eosinophilic Pneumonia: A Case Report and Systematic Review.

Chemotherapy. 2024;69(2):85-99

Patel YI, Natarajan S, Ramakrishna S, Ochieng P

Daptomycin-Induced Pulmonary Toxicity: A Case Series.

Cureus. 2023;15(5):e39613

Pham TT, Garreau R, Craighero F, Cottin V, Said BB, Goutelle S, Ferry T

Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm.

Open forum infectious diseases. 2022;9(11):ofac577

Abd Algayoum R, Elsherif A, Khan ZH, Roman G

Daptomycin-Induced Eosinophilic Pneumonia Mimicking Multifocal Pneumonia.

Cureus. 2022;14(10):e30521

West KA, Sheeti A, Tamura MacKay K, Forrest GN

Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia.

Open forum infectious diseases. 2022;9(4):ofac065

Somoza-Cano FJ, Makadia A, Cruz-Peralta MP, Zakarna L, Demyda E, Al Armashi AR, Patell K, Altaqi B

Acute Eosinophilic Pneumonia Secondary to Daptomycin.

Cureus. 2021;13(11):e19403

Watts A, Toquica Gahona CC, Raj K

Multifocal Pneumonia Amidst the Global COVID-19 Pandemic: A Case of Daptomycin-Induced Eosinophilic Pneumonia.

Cureus. 2021;13(6):e16002

Raman V, Chaudhary I, Shieh S

Eosinophilic pneumonia: a case of daptomycin induced lung injury.

Journal of community hospital internal medicine perspectives. 2021;11(2):280-285

Ahouansou N, Georges M, Beltramo G, Aswad N, Hassani Y, Bonniaud P

Daptomycin-induced eosinophilic pneumonia: Are there any risk factors?

Infectious diseases now. 2021;51(7):618-621

Portalatin GM, Chin JA, Foster B, Perry K, McWilliams C

Daptomycin-Induced Acute Eosinophilic Pneumonia.

Cureus. 2021;13(2):e13509

Raza A, Arslan A, Atiq MU, Chan V, Patel RK

Unexpected Outcome of Daptomycin-induced Eosinophilic Pneumonia: Rarity Within a Rarity.

Cureus. 2019;11(12):e6271

Basnet S, Tachamo N, Dhital R, Tharu B

Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses.

Journal of community hospital internal medicine perspectives. 2018;8(3):152-155

Bartal C, Sagy I, Barski L

Drug-induced eosinophilic pneumonia: A review of 196 case reports.

Medicine. 2018;97(4):e9688

Higashi Y, Nakamura S, Tsuji Y, Ogami C, Matsumoto K, Kawago K, Tokui K, Hayashi R, Sakamaki I, Yamamoto Y

Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature.

Internal medicine (Tokyo, Japan). 2018;57(2):253-258

Hirai J, Hagihara M, Haranaga S, Kinjo T, Hashioka H, Kato H, Sakanashi D, Yamagishi Y, Mikamo H, Fujita J

Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy. 2017;23(4):245-249

Uppal P, LaPlante KL, Gaitanis MM, Jankowich MD, Ward KE

Daptomycin-induced eosinophilic pneumonia - a systematic review.

Antimicrobial resistance and infection control. 2016;5:55

Durante-Mangoni E, Andini R, Parrella A, Mattucci I, Cavezza G, Senese A, Trojaniello C, Caprioli R, Diana MV, Utili R

Safety of treatment with high-dose daptomycin in 102 patients with infective endocarditis.

International journal of antimicrobial agents. 2016;48(1):61-68

Montenegro O, Del Campo R, Del Rio JJ, Ambrós Checa A

[Acute eosinophilic pneumonia secondary to daptomycin].

Enfermedades infecciosas y microbiologia clinica. 2016;34(6):390-1

Wojtaszczyk A, Jankowich M

Dyspnea on daptomycin: eosinophilic pneumonia.

Rhode Island medical journal (2013). 2015;98(6):41-3

Yusuf E, Perrottet N, Orasch C, Borens O, Trampuz A

Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection.

Surgical infections. 2014;15(6):834-7

Kim PW, Sorbello AF, Wassel RT, Pham TM, Tonning JM, Nambiar S

Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports.

Drug safety. 2012;35(6):447-57

Rether C, Conen A, Grossenbacher M, Albrich WC

A rare cause of pulmonary infiltrates one should be aware of: a case of daptomycin-induced acute eosinophilic pneumonia.

Infection. 2011;39(6):583-5

Kalogeropoulos AS, Tsiodras S, Loverdos D, Fanourgiakis P, Skoutelis A

Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature.

Journal of medical case reports. 2011;5:13

Hayes D Jr, Anstead MI, Kuhn RJ

Eosinophilic pneumonia induced by daptomycin.

The Journal of infection. 2007;54(4):e211-3