The Drug-Induced Respiratory Disease Website and App

Frequency - Incidence

Incidence of respiratory adverse event(s) due to the specific drug as assessed by number of reported/published cases in the literature. Red digits in stars indicate: 0 = Very rare, questionable signal · 1 = < 10 cases · 2 = 10-50 cases · 3 = 50–100 cases · 4 = 100-200 cases · 5 = >200 cases

Evidence level/grade

Evidence level for respiratory adverse event(s) due to the specific drug as estimated using Hill’s (1965), Naranjo’s (1981), and Bégaud’s (1985) criteria applied to published cases. Blue digits in stars indicate: 0 = Questionable · 1 = Low · 2 = Moderate · 3 = Robust · 4 = Definite · 5 = Unquestionable, pathognomonic

I.c

Eosinophilic pneumonia (pulmonary infiltrates and eosinophilia)

Publications

Utley LM, Larsen S, Goldberg T, Barjasteh T

Daptomycin and acute lung injury: recognising drug-induced eosinophilic pneumonia.

BMJ case reports 2025 Jul 18;18; — 2025 Jul 18

Shakour H, Mumtaz R, Abu-Samra AG

A Diagnostic Dilemma: Daptomycin-Induced Drug Reaction With Eosinophilia and Systemic Symptoms (DRESS) Syndrome and Eosinophilic Pneumonia With Concurrent COVID-19.

Cureus 2025 Jan;17;e77736 — 2025 Jan — e77736

Ayala Torres JD, Noreña B, Suarez Poveda AT

Eosinophilic Pneumonia Induced by Daptomycin.

Cureus 2024 Feb;16;e55095 — 2024 Feb

Di Lorenzo A, Rindi LV, Campogiani L, Imeneo A, Alessio G, Pace PG, Lodi A, Rossi B, Crea AMA, Vitale P, Kontogiannis D, Malagnino V, Andreoni M, Iannetta M, Sarmati L

Daptomycin-induced eosinophilic pneumonia: a case report and systematic review.

Chemotherapy 2023 Nov 14;; — 2023 Nov 14

Patel YI, Natarajan S, Ramakrishna S, Ochieng P

Daptomycin-Induced Pulmonary Toxicity: A Case Series.

Cureus 2023 May;15;e39613 — 2023 May — e39613

Pham TT, Garreau R, Craighero F, Cottin V, Said BB, Goutelle S, Ferry T

Seventeen Cases of Daptomycin-Induced Eosinophilic Pneumonia in a Cohort of Patients Treated for Bone and Joint Infections: Proposal for a New Algorithm.

Open forum infectious diseases 2022 Nov;9;ofac577 — 2022 Nov — ofac577

Abd Algayoum R, Elsherif A, Khan ZH, Roman G

Daptomycin-Induced Eosinophilic Pneumonia Mimicking Multifocal Pneumonia.

Cureus 2022 Oct;14;e30521 — 2022 Oct — e30521

West KA, Sheeti A, Tamura MacKay K, Forrest GN

Eosinophilic Syndromes Associated With Daptomycin Use: Re-exposure Hypersensitivity Pneumonitis and Prior Peripheral Eosinophilia.

Open forum infectious diseases 2022 Apr;9;ofac065 — 2022 Apr — ofac065

Somoza-Cano FJ, Makadia A, Cruz-Peralta MP, Zakarna L, Demyda E, Al Armashi AR, Patell K, Altaqi B

Acute Eosinophilic Pneumonia Secondary to Daptomycin.

Cureus 2021 Nov;13;e19403 — 2021 Nov — e19403

Watts A, Toquica Gahona CC, Raj K

Multifocal Pneumonia Amidst the Global COVID-19 Pandemic: A Case of Daptomycin-Induced Eosinophilic Pneumonia.

Cureus 2021 Jun;13;e16002 — 2021 Jun — e16002

Raman V, Chaudhary I, Shieh S

Eosinophilic pneumonia: a case of daptomycin induced lung injury.

Journal of community hospital internal medicine perspectives 2021 Mar 23;11;280-285 — 2021 Mar 23 — 280-285

Ahouansou N, Georges M, Beltramo G, Aswad N, Hassani Y, Bonniaud P

Daptomycin-induced eosinophilic pneumonia: Are there any risk factors?

Infectious diseases now 2021 Jan 09;; — 2021 Jan 09

Portalatin GM, Chin JA, Foster B, Perry K, McWilliams C

Daptomycin-Induced Acute Eosinophilic Pneumonia.

Cureus 2021 Feb 23;13;e13509 — 2021 Feb 23 — e13509

Raza A, Arslan A, Atiq MU, Chan V, Patel RK

Unexpected Outcome of Daptomycin-induced Eosinophilic Pneumonia: Rarity Within a Rarity.

Cureus 2019 Dec 02;11;e6271 — 2019 Dec 02 — e6271

Basnet S, Tachamo N, Dhital R, Tharu B

Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses.

Journal of community hospital internal medicine perspectives 2018;8;152-155 — 2018 — 152-155

Bartal C, Sagy I, Barski L

Drug-induced eosinophilic pneumonia: A review of 196 case reports.

Medicine 2018 Jan;97;e9688 — 2018 Jan — e9688

Higashi Y, Nakamura S, Tsuji Y, Ogami C, Matsumoto K, Kawago K, Tokui K, Hayashi R, Sakamaki I, Yamamoto Y

Daptomycin-induced Eosinophilic Pneumonia and a Review of the Published Literature.

Internal medicine (Tokyo, Japan) 2018 Jan 15;57;253-258 — 2018 Jan 15 — 253-258

Hirai J, Hagihara M, Haranaga S, Kinjo T, Hashioka H, Kato H, Sakanashi D, Yamagishi Y, Mikamo H, Fujita J

Eosinophilic pneumonia caused by daptomycin: Six cases from two institutions and a review of the literature.

Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy 2017 Apr;23;245-249 — 2017 Apr — 245-249

Uppal P, LaPlante KL, Gaitanis MM, Jankowich MD, Ward KE

Daptomycin-induced eosinophilic pneumonia - a systematic review.

Antimicrobial resistance and infection control 2016;5;55 — 2016 — 55

Durante-Mangoni E, Andini R, Parrella A, Mattucci I, Cavezza G, Senese A, Trojaniello C, Caprioli R, Diana MV, Utili R

Safety of treatment with high-dose daptomycin in 102 patients with infective endocarditis.

International journal of antimicrobial agents 2016 Jul;48;61-68 — 2016 Jul — 61-68

Montenegro O, Del Campo R, Del Rio JJ, Ambrós Checa A

[Acute eosinophilic pneumonia secondary to daptomycin].

Enfermedades infecciosas y microbiologia clinica 2016 Jun-Jul;34;390-1 — 2016 Jun-Jul — 390-1

Wojtaszczyk A, Jankowich M

Dyspnea on daptomycin: eosinophilic pneumonia.

Rhode Island medical journal (2013) 2015 Jun 01;98;41-3 — 2015 Jun 01 — 41-3

Yusuf E, Perrottet N, Orasch C, Borens O, Trampuz A

Daptomycin-associated eosinophilic pneumonia in two patients with prosthetic joint infection.

Surgical infections 2014 Dec;15;834-7 — 2014 Dec — 834-7

Kim PW, Sorbello AF, Wassel RT, Pham TM, Tonning JM, Nambiar S

Eosinophilic pneumonia in patients treated with daptomycin: review of the literature and US FDA adverse event reporting system reports.

Drug safety 2012 Jun 01;35;447-57 — 2012 Jun 01 — 447-57

Rether C, Conen A, Grossenbacher M, Albrich WC

A rare cause of pulmonary infiltrates one should be aware of: a case of daptomycin-induced acute eosinophilic pneumonia.

Infection 2011 Dec;39;583-5 — 2011 Dec — 583-5

Kalogeropoulos AS, Tsiodras S, Loverdos D, Fanourgiakis P, Skoutelis A

Eosinophilic pneumonia associated with daptomycin: a case report and a review of the literature.

Journal of medical case reports 2011 Jan 17;5;13 — 2011 Jan 17 — 13

Hayes D, Anstead MI, Kuhn RJ

Eosinophilic pneumonia induced by daptomycin.

The Journal of infection 2007 Apr;54;e211-3 — 2007 Apr — e211-3